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KMID : 0380020070220050341
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Korean Journal of Biotechnology and Bioengineering
2007 Volume.22 No. 5 p.341 ~ p.344
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Anti-obesity Effects of Ginsenoside Rd via AMPK and PPAR Gamma
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Lee Myeong-Soo
Kim Soon-Hee
Kim Seong-Hee
Kim Hyeon-Jin
Sung Mi-Jung
Kim Hye-Young
Kwon Dae-Young
Hwang Jin-Taek
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Abstract
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Obesity is a major obstacle for human health, which induces various diseases such as cardiac injury and type 2 diabetes. Ginsenosides, active components of ginseng extract, exert various physiological effects. However, There are still no evidence for their anti obesity effects. In this study, we investigated the effects of ginsenoside Rd on adipocyte differentiation in 3T3-L1 cells. Our data show that ginsenoside Rd (80 uM) was effective in adipocyte differentiation inhibition. These inhibitory effects of ginsenosides on adipocyte differentiation were accompanied by PPAR gamma inhibition in rosiglitazone-treated cells. We also tested whether AMP-activated protein kinase (AMPK) activation was involved in the effects of these ginsenosides. AMPK is a master target for obesity, ginsenoside Rd significantly activated AMPK. Taken together, these results suggest that the anti obesity effects of ginsenoside Rd involve the AMPK signaling pathway and PPAR-gamma inhibition.
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KEYWORD
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Anti-obesity, ginsenoside, AMP-activated protein kinase, PPAR-, (peroxisome proliferator activated receptor), 3T3-L1 adipocyte
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